期刊
ORGANIC LETTERS
卷 15, 期 2, 页码 274-277出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol303110d
关键词
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资金
- Natural Science Foundation of China [21072204, 21021063, 81273430]
- National Marine 863 Project [2011AA09070102, 2013AA092902]
- SKLDR/SIMM [SIMM1203ZZ-03]
- Hungarian National Research Foundation [OTKA K105871]
Methyl sarcotroates A and B (3 and 4), two unprecedented diterpenoids possessing a tetradecahydrocyclopenta[3',4']cyclobuta[1',2':4,5]-cyclonona[1,2-b]oxirene ring system, along with their probable biogenetic precursor, sarcophytonolide M (1), were isolated from the Hainan soft coral Sarcophyton trocheliophorum. Their structures were elucidated by detailed spectroscopic analysis, and the absolute configuration of compound 3 was determined by TDDFT ECD calculations. Compound 4 exhibited significant inhibitory activity against protein tyrosine phosphatase 1B (PTP1B), being similar to that of positive control oleanolic acid.
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