期刊
ORGANIC LETTERS
卷 14, 期 13, 页码 3288-3291出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol301243f
关键词
-
资金
- National Science Foundation [CHE-1059084, CHE-1012979, OCI-1053575]
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [1012979, 1059084] Funding Source: National Science Foundation
Density functional theory (DFT) calculations were performed to investigate the origins of enantioselectivity in benzotetramisole (BTM)-catalyzed dynamic kinetic resolution of azlactones. The transition states of the fast-reacting enantiomer are stabilized by electrostatic interactions between the amide carbonyl group and the acetate anion bound to the nucleophile. The chiral BTM catalyst confines the conformation of the a-carbon and the facial selectivity of the nucleophilic attack to promote such electrostatic attractions.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据