期刊
ORGANIC LETTERS
卷 14, 期 22, 页码 5808-5810出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol3024665
关键词
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资金
- NIH [S10 RR019022]
- Department of Pharmacology
- William K. Warren, Jr. Funding
The first total synthesis of Aplidiopsamine A, a rare 3H-pyrrolo[2,3-c]quinoline alkaloid from the Aplidiopsis confluata, has been achieved following the proposed biosynthesis. This biomimetic synthesis requires only five steps and proceeds in 20.8% overall yield. Biological evaluation across large panels of discrete molecular targets identified that Aplidiopsamine A is a highly selective PDE4 inhibitor, a target for numerous CNS disorders.
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