4.8 Article

Addition of Indoles to Oxyallyl Cations for Facile Access to α-Indole Carbonyl Compounds

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ORGANIC LETTERS
卷 14, 期 7, 页码 1922-1925

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AMER CHEMICAL SOC
DOI: 10.1021/ol300591z

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  1. Singapore National Research Foundation (NRF)
  2. Singapore Economic Development Board (EDB)
  3. GlaxoSmithKline (GSK)
  4. Nanyang Technological University (NTU)

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A direct coupling of unprotected indoles and alpha-halo ketones via in situ generated oxyallyl cation intermediates is described. The reactions efficiently afford a-indole carbonyl compounds with good to quantitative yields.

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