期刊
ORGANIC LETTERS
卷 14, 期 6, 页码 1464-1467出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol300202z
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- Ministry of Land, Transport and Maritime Affairs, Korea
Ieodoglucomides A (1) and B (2), unique glycolipopeptides consisting of an amino acid, a new fatty acid, a succinic acid, and a sugar, were isolated from a Marine-derived bacterium Bacillus licheniformis. The absolute stereochemistry of 1 and 2 was determined by deploying coupling constants, Marfey's and Mosher's methods, and literature reviews. Compounds 1 and 2 displayed moderate in vitro antimicrobial activity. Furthermore, ieodoglucomide B (2) exhibited cytotoxic activity against lung cancer and stomach cancer cell lines with GI(50) values of 25.18 and 17.78 mu g/mL, respectively.
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