期刊
ORGANIC LETTERS
卷 14, 期 9, 页码 2422-2425出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol3008638
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资金
- National Basic Research Program of China [2010CB833800]
- National Natural Science Foundation of China [21172204, 30973680, 30670219]
- Major Program for Technique Development Research of New Drugs in China [2009ZX09103-046]
- Special Fund for Marine Scientific Research in the Public Interest of China [2010418022-3]
Streptocarbazoles A (1) and B (2), two novel indolocarbazoles featuring unprecedented cyclic N-glycosidic linkages between 1,3-carbon atoms of the glycosyl moiety and two indole nitrogen atoms of the indolocarbazole core, were isolated from the marine-derived actinomycetes strain Streptomyces sp. FMA. Their structures were established by spectroscopic methods, CD spectra, and ECD quantum mechanical calculations. Compound 1 was cytotoxic on HL-60 and A-549 cell lines and could arrest the cell cycle of Hela cells at the G(2)/M phase.
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