Ligand-Free Ni-Catalyzed Reductive Cleavage of Inert Carbon-Sulfur Bonds

A catalytic reductive cleavage of C(sp(2))-and C(sp(3))-SMe bonds under ligandless conditions is presented. The method is characterized by its wide scope and high chemoselectivity profile including challenging substrate combinations, allowing the design of orthogonal and site-selectivity approaches.