期刊
ORGANIC LETTERS
卷 14, 期 13, 页码 3498-3501出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol3014705
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资金
- Ministry of Education, Culture, Sports, Science and Technology of Japan
Two new structurally unique dimeric sesquiterpenoids, halichonadins K (1) and L (2), were isolated from an Okinawan marine sponge Halichondria sp. The structures of 1 and 2 were elucidated on the basis of spectroscopic analysis including a single crystal X-ray diffraction analysis and chemical conversion. Halichonadins K (1) and L (2) are homodimers of the eudesmane sesquiterpene linked with a piperidine ring through amide bonds. Halichonadin K (1) showed moderate cytotoxicity against KB cells.
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