期刊
ORGANIC LETTERS
卷 14, 期 17, 页码 4486-4489出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol3019874
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资金
- Marine Biotechnology Program
- Ministry of Land, Transport and Maritime Affairs of Korea
A chemical investigation of a Korean marine sponge, Phorbas sp., yielded unprecedented sesterterpenoids phorone A (1) and isophorbasone A (2) along with ansellone B (3) and phorbasone A acetate (4). Their complete structures were elucidated by the combination of spectroscopic data and chemical manipulation. Phorone A (1) and isophorbasone A (2) have the new phorane (5) and isophorbasane' (6) sesterterpenoid carbon skeletons, respectively. Ansellone B (3) and phorbasone A acetate (4) exhibited potent inhibitory activity on nitric oxide production in RAW 264.7 LPS-activated mouse macrophage cells with IC50 values of 4.5 and 2.8 mu M, respectively.
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