期刊
ORGANIC LETTERS
卷 14, 期 6, 页码 1432-1435出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol300178j
关键词
-
资金
- National Institutes of Health [GM58160, F32GM097771]
- National Science Foundation [CHE-9808061]
A method for the Pd-catalyzed coupling of 2-aminothiazole derivatives with aryl bromides and triflates is described. Significantly, for this class of nucleophiles, the coupling exhibits a broad substrate scope and proceeds with a reasonable catalyst loading. Furthermore, an interesting effect of acetic acid as an additive is uncovered that facilitates catalyst activation.
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