期刊
ORGANIC LETTERS
卷 14, 期 5, 页码 1218-1221出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol203444g
关键词
-
资金
- CAS
- State Key Laboratory of Fine Chemicals [KF1008]
A novel protocol for the highly stereoselective synthesis of E,E-alpha,beta,gamma,delta-unsaturated dicarbonyl compounds is presented. Starting from the readily available allylic alcohols and 1,3-cliketones, an array of E,E-alpha,beta,gamma,delta-dienones can be efficiently synthesized in high yields via Pd-catalyzed dehydrative allylation, H-migration, and aerobic oxidative 6-hydride elimination cascade. In addition to the novel reaction mechanism, the use of 1:1 allylic alcohol and 1,3-diketone as reactant, 5 mol % of PdCl2 as catalyst, and 1 atm of environmentally benign 02 as oxidant, as well as the generation of only H2O byproduct, makes this protocol rapid, simple, atom-efficient, and clean.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据