期刊
ORGANIC LETTERS
卷 14, 期 4, 页码 1016-1019出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol2033674
关键词
-
资金
- EPSRC
- EC [IEF] [PIEF-GA-2009-254068]
- EPSRC [EP/G007802/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/G007802/1] Funding Source: researchfish
A new cascade reaction involving an intramolecular Michael addition followed by an alkyne carbocyclization is presented. The reaction is promoted by a substoichiometric amount of KHMDS and represents one of the rare examples where the carbocyclization of an unactivated alkyne is mediated by an alkali metal base, under mild conditions. The reaction allows the generation of functionally dense, stereochemically defined, tricyclic structures possessing three adjacent stereocenters in good yields and with high stereoselectivity.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据