Jacobsen Protocols for Large-Scale Epoxidation of Cyclic Dienyl Sulfones: Application to the (+)-Pretazettine Core

A Jacobsen epoxidation protocol using H2O2 as oxidant was designed for the large-scale preparation of various epoxy vinyl sulfones. A number of cocatalysts were screened, and pH control led to increased reaction rate, higher turnover number, and improved reliability.