Concise Synthesis of α-Trisubstituted Amines from Ketones Using N-Methoxyamines

Three-component allylation and cyanation utilizing a ketone and an N-methoxyamine are reported. The high nucleophilicity of the N-methoxyamine and high electrophilicity of the corresponding iminium ion enable the concise synthesis of alpha-trisubstituted amines in a single step.