期刊
ORGANIC LETTERS
卷 14, 期 14, 页码 3736-3739出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol301593w
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资金
- NIGMS [R01 GM084254]
A formal synthesis of 7-methoxymitosene is achieved via a key platinum-catalyzed cycloisomerization. The precursor for the Pt catalysis, a fully functionalized benzene intermediate, was prepared via a regioselective electrophilic bromination followed by a chemoselective Sonogashira cross-coupling. It underwent the PtCl2-catalyzed cycloisomerization smoothly despite its hindered and highly electron-rich nature. Analogs of 7-methoxymitosene can be accessed in an expedient manner by following a similar synthetic sequence.
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