期刊
ORGANIC LETTERS
卷 14, 期 15, 页码 3818-3821出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol301218x
关键词
-
资金
- National Natural Science Foundation of China [21072031, 20802009]
- Shanghai Municipal Committee of Science and Technology [10ZR1404100]
A one-pot dual-organocatalyst-promoted asymmetric alpha-aminoxylation/aza-Michael/aldol consendation cascade reaction is presented. The targeted optically active 1,2-oxazine derivatives are synthesized in moderate yields (up to 70%), excellent enantioselectivities (ee >99% in all cases), and excellent diastereoselectivities (dr up to >99:1) under mild conditions. To further elucidate the synthetic utility of the cascade products, cleavage of the N-O bond is demonstrated and an enantiopure syn-1,4-amino alcohol derivative is achieved in excellent yield.
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