4.8 Article

Improved Protocol for Indoline Synthesis via Palladium-Catalyzed Intramolecular C(sp2)-H Amination

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ORGANIC LETTERS
卷 14, 期 12, 页码 2944-2947

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AMER CHEMICAL SOC
DOI: 10.1021/ol301352v

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  1. Pennsylvania State University
  2. U.S. National Science Foundation [CHE-1055795]
  3. ACS-PFR [51705-DNI1]
  4. Direct For Mathematical & Physical Scien
  5. Division Of Chemistry [1055795] Funding Source: National Science Foundation

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An efficient method has been developed for the synthesis of indoline compounds from picolinamide (PA)-protected beta-arylethylamine substrates via palladium-catalyzed intramolecular amination of ortho-C(sp(2))-H bonds. These reactions feature high efficiency, low catalyst loadings, mild operating conditions, and the use of inexpensive reagents.

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