4.8 Article

A General, Enantioselective Synthesis of Protected Morpholines and Piperazines

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ORGANIC LETTERS
卷 14, 期 11, 页码 2910-2913

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AMER CHEMICAL SOC
DOI: 10.1021/ol301203z

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  1. Department of Pharmacology, Vanderbilt University Medical Center
  2. Vanderbilt Specialized Chemistry Center for Accelerated Probe Development/MLPCN [U54MH084659]
  3. ACS Division of Medicinal Chemistry
  4. NIH [S10 RR019022]

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A short, high yielding protocol has been developed for the enantioselective and general synthesis of C2-functionalized, benzyl protected morpholines and orthogonally N,N'-protected piperazines from a common intermediate.

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