4.8 Article

Pd-Catalyzed β-Selective Direct C-H Bond Arylation of Thiophenes with Aryltrimethylsilanes

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ORGANIC LETTERS
卷 14, 期 24, 页码 6186-6189

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AMER CHEMICAL SOC
DOI: 10.1021/ol3029109

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  1. MEXT, Japan
  2. New Energy and Industrial Technology Development Organization (NEDO)
  3. Grants-in-Aid for Scientific Research [22550093] Funding Source: KAKEN

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Direct arylation of thiophenes and benzothiophenes with aryltrimethylsilanes was effectively catalyzed by PdCl2(MeCN)(2) in the presence of CuCl2 as an oxidant. The reaction preferentially occurred at the beta-position of both thiophenes and benzothiophenes.

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