期刊
ORGANIC LETTERS
卷 14, 期 24, 页码 6210-6213出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol302958e
关键词
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资金
- Robert A. Welch Foundation [Y-1362]
- NIH [GM065503]
- NSF [CHE-0234811, CHE-0840509]
Short total syntheses of the Leucetta-derived alkaloids, kealiinines A-C, have been accomplished using an intramolecular Friedel-Crafts-dehydration sequence of a bis benzylic diol. The precursor diol was obtained through a series of position-specific Grignard reactions from 1-methyl-4,5-diiodoimidazole. C2-Azidation and hydrogenation of the azide then provided the reported structures of kealiinines A-C. While the H-1 NMR data did not completely match for these materials, the HPLC data were consistent with the assigned structure of these alkaloids.
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