Concise Total Synthesis of (-)-8-Epigrosheimin

A highly efficient route was developed to synthesize (-)-8-epigrosheimin In four steps from aldehyde 2 based on a substrate-controlled method. The key steps of the synthesis included (1) a stereo- and regioselective allylation addition, (2) an intramolecular translactonization, and (3) an aldehyde-ene cyclization.