4.8 Article

Palladium-Catalyzed Direct ortho-Alkynylation of Aromatic Carboxylic Acid Derivatives

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ORGANIC LETTERS
卷 14, 期 1, 页码 354-357

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AMER CHEMICAL SOC
DOI: 10.1021/ol203100u

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  1. The Ministry of Education, Culture, Sports, Science and Technology, Japan.
  2. JSPS
  3. Grants-in-Aid for Scientific Research [10J00248] Funding Source: KAKEN

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The palladium-catalyzed direct alkynylation of C-H bonds in aromatic carboxylic acid derivatives is described. The use of 8-aminoquinoline as a directing group facilitates the alkynylation of an electronically diverse range of C(sp(2))-H bonds.

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