期刊
ORGANIC LETTERS
卷 13, 期 22, 页码 6102-6105出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol202597b
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资金
- National Science Foundation of China [21072022]
- Specialized Research Fund for the Doctoral Program of Higher Education [20100003110010]
- Fundamental Research Funds for the Central Universities
Facile arylation and alkylation of nitropyridine N-oxides were developed through the reactions of Grignard reagents with nitropyridine N-oxides. For the same 4-nitropyridine N-oxide, arylation occurred at the 2- (or 6-) position, whereas alkylation occurred at the 3-position in an adjustably site-selective manner. The cooperative action of the two groups was discovered in the reactions of 3-nitropyridine N-oxides. This protocol can find wide applications In building various pyridine compounds as illustrated in total syntheses of Emoxipin and Caerulomycin A and E.
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