期刊
ORGANIC LETTERS
卷 13, 期 5, 页码 920-923出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol1029707
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资金
- ANT Technology (Taipei, Taiwan)
- National Science Council (Taiwan, ROC)
Starting with inexpensive reagents, a self-directed chemical process with the aid of a single metal triflate was readily achieved to concomitantly construct quinazoline and pyrroloquinoline cores to afford the synthesis of luotonin A and its analogues. Among all compounds prepared, 2c, 2d, and 3b exhibit more potent inhibitory activity than luotonin A against human topoisomerase I.
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