4.8 Article

CuO-Promoted Construction of N-2-Aryl-Substituted-1,2,3-Triazoles via Azide-Chalcone Oxidative Cycloaddition and Post-Triazole Arylation

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ORGANIC LETTERS
卷 14, 期 1, 页码 26-29

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AMER CHEMICAL SOC
DOI: 10.1021/ol202718d

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资金

  1. Scientific Research Foundation for the State Education Ministry [107108]
  2. Project of National Science Foundation of P. R. China [J0730425]

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An efficient one-pot three-component stepwise approach for the synthesis of N-2-aryl-substituted-1,2,3-triazoles has been developed. By using this azide-chalcone oxidative cycloaddition and post-triazole arylation, a series of N-2-aryl-substituted-1,2,3-triazoles are readily prepared under mild conditions in excellent yields and high regioselectivity. Both the catalyst and substrates are readily available.

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