期刊
ORGANIC LETTERS
卷 13, 期 9, 页码 2334-2337出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol200584a
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资金
- Deutsche Forschungsgemeinschaft [Ma 1012/25-1]
- Fonds der Chemischen Industrie
- state Baden-Wurttemberg
The synthesis of the 16-membered core structure of leiodermatolide 40 has been achieved in 26 linear steps starting from (R)-Roche ester. The key steps in the synthesis of 40 are a Stille cross-coupling between two main fragments 11 and 33 having roughly equal size. For the trisubstituted C4/C5 double bond a carbometalation reaction followed by a Suzuki coupling was used. A Yamaguchi macrolactonization furnished macrolactone 39.
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