期刊
ORGANIC LETTERS
卷 13, 期 12, 页码 3232-3234出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol2011264
关键词
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资金
- MEXT [22000008]
- Global COE Program for Chemistry Innovation
- University of Tokyo
- Grants-in-Aid for Scientific Research [22000008, 23750100] Funding Source: KAKEN
Aromatic carboxamides and 2-phenylpyridine derivatives can be ortho-alkylated with Grignard reagents in the presence of a cobalt catalyst and DMPU as a ligand. The reaction proceeds smoothly at room temperature, using air as the sole oxidant. The dialkylated product is selectively obtained when N-methylcarboxamide is employed as a substrate, whereas N-phenyl- or N-isopropylcarboxamide preferentially gives the monoalkylated product.
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