期刊
ORGANIC LETTERS
卷 13, 期 20, 页码 5600-5603出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol202326j
关键词
-
资金
- NSFC [20972117, NCET-10-0649, IRT1030]
- 973 Program [2011CB808600]
- Fundamental Research Funds for the Central Universities
A direct and facile access to enantioenriched pyroglutamate derivatives bearing a unique quaternary stereogenic center has been developed via Cu(I)/BINAP-catalyzed tandem Michael addition-elimination of alpha-substituted aldimino esters with Morita-Baylis-Hillman (MBH) carbonates followed by a deprotection/lactamization protocol, which performs well over a broad scope of substrates and provides biologically active pyroglutamate derivatives in good yields and excellent enantioselectivities.
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