期刊
ORGANIC LETTERS
卷 13, 期 15, 页码 3936-3939出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol2014494
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资金
- NSERC
- NIH
- NSF
- CIHR
- RIKEN
Two highly modified linear tetrapeptides, padanamides A (1) and B (2), are produced by laboratory cultures of a Streptomyces sp. obtained from a marine sediment. Padanamide B is cytotoxic to Jurkat cells, and a chemical genomics analysis using Saccharomyces cerevislae deletion mutants suggested that padanamide A inhibits cysteine and methionine biosynthesis or that these amino acids are involved in the yeast's response to the peptide.
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