期刊
ORGANIC LETTERS
卷 13, 期 7, 页码 1642-1645出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol2001057
关键词
-
资金
- Slovak grant agency [1/0629/08]
The practical stereodivergent route to both syn- and anti-diastereomers of 1-substituted 3-aminobutane-1,4-diols based on the crystallization-induced asymmetric transformation (CIAT) approach was completed. This led to the revision of the reported stereochemistry of the first inhibitor of CERT-dependent ceramide trafficking HPA-12 from (R,R)-anti- to the (R,S)-syn-enantiomer. Due to the expeditiousness of production and inexpensive conditions developed, a series of alkyl- and aryl-substituted analogues of HPA-12 is also reported.
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