cis-2,5-Diaminobicyclo[2.2.2]octane, a New Scaffold for Asymmetric Catalysis via Salen-Metal Complexes

A new C(2) symmetric salen scaffold based on cis-2,5-diaminobicyclo[2.2.2]octane has been synthesized that forms complexes with a wide range of metals. The chromium(III) complex is shown to catalyze the hetero-Diels-Alder reaction and the Nozaki-Hiyama-Kishi reaction with high efficiency and excellent stereoselectivity.