期刊
ORGANIC LETTERS
卷 14, 期 1, 页码 202-205出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol202994c
关键词
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资金
- National Natural Science Foundation of China [81072573, 81172978, 41106127, 81001394]
- STCSM [09dZ1975800]
- National High Technology Research and Development Program of China (863 Project) [2011AA-090701]
Dysidavarones A-D (1-4), four new sesquiterpene quinones possessing the unprecedented dysidavarane carbon skeleton, were isolated from the South China Sea sponge Dysidea avara. The structures were established by spectroscopic methods, and the absolute configurations were determined using quantum mechanical calculation of the electronic circular dichroic (ECD) spectrum and exciton chirality CD method. Their cytotoxic activity against four human cancer cell lines and PTP1B inhibitory activity were also evaluated.
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