期刊
ORGANIC LETTERS
卷 13, 期 5, 页码 952-955出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol102998w
关键词
-
资金
- Sumitomo Foundation
- JSPS
A concise enantioselective synthetic route to a potent GPR40 agonist AMG 837 is described. The crucial catalytic asymmetric conjugate addition of terminal alkyne was promoted by a soft Lewis acid/hard Bronsted base cooperative catalyst, allowing efficient construction of the requisite stereogenic center. The thioamide functional group is key to both activation in asymmetric alkynylation and facile transformation into carboxylic acid.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据