期刊
ORGANIC LETTERS
卷 13, 期 18, 页码 4822-4825出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol201899c
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资金
- National Institutes of Health (NIH) [GM-082935]
- National Science Foundation [NSF-0847108]
The first catalytic asymmetric method to prepare enantioenriched N,S-acetals using chiral BINOL phosphoric acids is reported. The reaction combines N-acyl imines with thiols to generate products in excellent yield and enantioselectivity. The addition reaction could also be achieved with an exceptional substrate to catalyst (SIC) molar ratio. Electron-rich and electron-deficient aromatic N-acyl imines, as well as a broad range of aliphatic and aromatic thiols, showed excellent reactivity.
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