期刊
ORGANIC LETTERS
卷 13, 期 16, 页码 4264-4267出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol201613a
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资金
- University of York
- EPSRC [EP/E041302/1]
- AstraZeneca
- Marie Curie International Outgoing Fellowship [FP7]
- EPSRC [EP/E041302/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/E041302/1] Funding Source: researchfish
An asymmetric decarboxylative palladium-catalyzed allylation of alkyl- and aryl-substituted oxindoles has been developed, enabling the installation of an all-carbon quaternary chiral center at the oxindole 3-position in excellent yields and good to excellent enantioselectivity. An intriguing substrate-dependent reversal in stereoselectivity has been observed, whereby the size of the substituent determines the facial selectivity in the allylation step.
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