期刊
ORGANIC LETTERS
卷 13, 期 19, 页码 5032-5035出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol201809q
关键词
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资金
- National S & T Major Project [2009ZX09301-001]
- National Marine 863 Project [2011AA090071-2]
- Natural Science Foundation of China [40976048, 31070310, 21021063]
- EU
- NSFC-TRF [20911140471]
- CAS [KSCX2-YW-R-18]
- STCSM [10540702900]
A novel alpha-alkylbutenolide dimer, paracaseolide A (2), characterized by an unusual tetraquinane oxa-cage bislactone skeleton bearing two linear alkyl chains, was isolated from the mangrove plant Sonneratia paracaseolaris. The structure of 2 was elucidated by extensive spectroscopic analysis. A plausible retrosynthetic pathway for paracaseolide A (2) was proposed. Compound 2 exhibited significant inhibitory activity against dual specificity phosphatase CDC25B, a key enzyme for cell cycle progression, with an IC50 value of 6.44 mu M.
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