期刊
ORGANIC LETTERS
卷 13, 期 17, 页码 4736-4737出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol202056w
关键词
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资金
- Cephalon, Inc.
Concise asymmetric total syntheses of Strychnos alkaloids (-)-leuconicine A (14 steps, 9% overall yield) and B (13 steps, 10% overall yield) have been accomplished. Key steps include (1) our sequential one-pot spiro-cyclization/intramolecular aza-Baylis-Hillman method to prepare the ABCE framework; (2) a novel domino acylation/Knoevenagel cyclization to prepare the F-ring; and (3) a Heck cyclization to access the D-ring.
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