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卷 13, 期 18, 页码 4866-4869出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol201943g
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资金
- National Natural Science Foundation of China [21072145]
- Foundation for the Author of National Excellent Doctoral Dissertation of P.R. China [200931]
- Natural Science Foundation of Jiangsu Province of China [BK2009115]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
The combination of a cinchona-based chiral primary amine and a BINOL-phosphoric acid has been demonstrated as a powerful and synergistic catalyst system for the double Michael addition of isatylidene malononitriles with alpha,beta-unsaturated ketones, to provide the novel chiral Spiro [cyclohexane-1,3'-indoline]-2',3-diones in high yields (88-99%) with excellent diastereo- and enantioselectivities (94:6-99:1 dr's, 95-99% ee's).
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