Synthesis of α-CF3-Substituted Carbonyl Compounds with Relative and Absolute Stereocontrol Using Electrophilic CF3-Transfer Reagents

Evans-type chiral lithium imide enolates undergo diastereoselective alpha-trifluoromethylation with a hypervalent Iodine-CF3 reagent with up to 91% combined Isolated yield and 97:3 dr. The resulting isolated dlastereopure products can be further transformed into valuable products without racemization.