Peptide/Laccase Cocatalyzed Asymmetric α-Oxyamination of Aldehydes

An asymmetric alpha-oxyamination could be successfully performed by a peptide catalyst and laccase. The combination of peptide catalysis and enzymatic air oxidation promoted the reaction smoothly in water without employing a metal reagent. The oxyaminated compounds could be obtained as both aldehyde and carboxylic acid products depending on the reaction conditions.