期刊
ORGANIC LETTERS
卷 13, 期 17, 页码 4664-4667出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol201877v
关键词
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资金
- Council of Scientific and Industrial Research, New Delhi
- CAS Instrumentation Facility, Department of Chemistry, University of Calcutta
- UGC [37-398/2009 (SR)]
This is the first report of an Innovative, one-pot, catalyst-free, pseudo-five-component synthesis of 1,2-dihydro[1,6]naphthyridines from methyl ketones, amines, and malononitrile In ecofriendly solvent water. The protocol avoids the use of expensive catalysts, toxic organic solvents and anhydrous condition. The approach to naphthyridines presented herein offers for the first time an unprecedented coupling which leads to the construction of both the nitrogen containing rings during the synthesis without starting from any nitrogen-containing heterocycle moiety.
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