Solomonamides A and B, New Anti-inflammatory Peptides from Theonella swinhoei

Two unprecedented cyclic peptides, solomonamides A and B, were Isolated from the marine sponge Theonella swinhoel. The structures were elucidated on the basis of comprehensive 1D and 2D NMR analysis and high-resolution mass spectrometry. A combined approach, involving Marfey's method, QM J based analysis, and DFT J/C-13 calculations, was used for establishing the absolute configuration of the entire molecule. Solomonamide A showed in vivo anti-inflammatory activity.