期刊
ORGANIC LETTERS
卷 12, 期 3, 页码 412-415出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol902433a
关键词
-
资金
- National Institutes of Health [HG005033, GM079590, GM081261]
The first continuous flow synthesis of imidazo[1,2-a]pyridine-2-carboxylic acids directly from 2-aminopyridines and bromopyruvic acid has been developed, representing a significant advance over the corresponding in-flask method. The process was applied to the multistep synthesis of imidazo[1,2-a]pyridine-2-carboxamides, including a Mur ligase inhibitor, using a two microreactor, multistep continuous flow process without isolation of intermediates.
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