Catalytic Asymmetric Domino Michael Addition-Alkylation Reaction: Enantioselective Synthesis of Dihydrofurans

A catalytic enantioselective synthesis of dihydrofurans has been developed. 1,3-Dicarbonyl derivatives react with (E)-beta,beta-bromonitrostyrenes in the presence of a chiral bifunctional thiourea catalyst providing mild and efficient access to diverse polysubstituted dihydrofurans in good yields and enantioselectivities.