4.8 Article

Pd(OAc)2-Catalyzed Regioselective Arylation of Indoles with Arylsiloxane in Acidic Medium

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ORGANIC LETTERS
卷 12, 期 14, 页码 3185-3187

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AMER CHEMICAL SOC
DOI: 10.1021/ol101147b

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  1. Natural Science Foundation of China [20872126]
  2. Zhejiang Provincial Natural Science Foundation of China [R407106]

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Mild conditions have been developed to achieve a Pd(OAc)(2)-catalyzed cross-coupling between indoles and arylsiloxanes in the presence of TBAF and Ag2O in acidic medium. Electron-deficient arylsiloxanes presented high efficiency in this system to give the arylated indoles in excellent yields.

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