期刊
ORGANIC LETTERS
卷 12, 期 14, 页码 3132-3135出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol1009224
关键词
-
资金
- NSFC [20802074]
- National Basic Research Program of China (973 Program) [2010CB833300]
The first enantioselective organocatalytic two- and three-component reactions via a domino Knoevenagel/Michael/cyclization sequence with cupreine as catalyst have been developed. A wide range of optically active spiro[4H-pyran-3,3'-oxindoles] were obtained in excellent yields (up to 99%) with good to excellent enantioselectivities (up to 97%) from simple and readily available starting materials under mild reaction conditions. These heterocyclic spirooxindoles will provide promising candidates for chemical biology and drug discovery.
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