期刊
ORGANIC LETTERS
卷 12, 期 20, 页码 4458-4461出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol101396n
关键词
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资金
- NIH [CA 47135, CA 052955]
- FIC/NIH [u0TTW008160]
- Lanzhou Univeisity [LZU1C2007005]
- [2007CB108903]
Azonazine. a unique hexacyclic dipeptide, was isolated from a Hawaiian marine sediment-derived fungus eventually identified as Aspergillus insulicola. Its absolute configuration, 2R,10R,11S,19R, was established using NMR, HRESIMS, and CD data plus insights derived from molecular models A possible route for its biogenesis is proposed, and biological properties were explored against cancer cell lines and in an NF kappa B inhibition assay
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