期刊
ORGANIC LETTERS
卷 12, 期 23, 页码 5442-5445出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol102155h
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资金
- EPSRC
- AstraZeneca
- AZ-GSK-Pfizer
- DAM
On lithiation with lithium amides, N-allyl-N'-aryl ureas undergo rearrangement with transfer of the aryl ring from N to the allylic alpha carbon. From the alpha-arylated products, a further aryl transfer under the influence of a chiral lithium amide allows the enantioselective construction of 1,1-diarylallylamine derivatives. Stereoselectivity in these reactions results from the enantioselective formation of a planar chiral allyllithium under kinetic control.
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