4.8 Article

Decarboxylative Cross-Coupling of Azoyl Carboxylic Acids with Aryl Halides

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ORGANIC LETTERS
卷 12, 期 21, 页码 4745-4747

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AMER CHEMICAL SOC
DOI: 10.1021/ol1019597

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  1. EPSRC
  2. EPSRC [EP/G007519/1] Funding Source: UKRI
  3. Engineering and Physical Sciences Research Council [EP/G007519/1] Funding Source: researchfish

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Decarboxylative cross-coupling of thiazole and oxazole-5-carboxylic acids with aryl halides is reported. Under a bimetallic system of catalytic palladium and a stoichiometric silver carbonate, a variety of (hetero)arylated azoles can be prepared in excellent yield.

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