4.8 Article

TBHP/I2-Mediated Domino Oxidative Cyclization for One-Pot Synthesis of Polysubstituted Oxazoles

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ORGANIC LETTERS
卷 12, 期 23, 页码 5561-5563

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AMER CHEMICAL SOC
DOI: 10.1021/ol1023085

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资金

  1. National Natural Science Foundation of China [20625205, 20772034, 20932002]
  2. National Basic Research Program of China (973 Program) [2011CB808600]
  3. Ministry of Education of China [20090172110014]
  4. Guangdong Natural Science Foundation [10351064101000000]

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A facile type of one-pot, transition-metal-free domino process was developed for the synthesis of oxazoles. Thus, a variety of polysubstituted oxazoles were easily synthesized via t-BuOOH/(2)-mediated domino oxidative cyclization from readily available starting materials under mild conditions.

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